Abstract
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated affair, in which several pathways compete for the DNA ends in a complex balance. Thus, the fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues. Among those different tiers of regulation, RNA modifications have just emerged as a promising field.
Highlights
RNA Modifications in DNA RepairMany different aspects of cellular biology impact the outcome of the double-strand breaks (DSBs) repair
Specialty section: This article was submitted to Protein and RNA Networks, a section of the journal Frontiers in Molecular Biosciences
The fine-tuning of the DNA double-strand break repair pathway choice relies on the different regulatory layers that respond to environmental cues
Summary
Many different aspects of cellular biology impact the outcome of the DSB repair. Among them, it has become clear in recent years that the RNA itself and RNA-related proteins play some essential roles (for review, see Jimeno et al, 2019). We focus on the emerging significance of RNA modifications for DSB repair
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