Abstract
Oral cancer is one among the leading causes of death in developing countries of south Asia. A very high incidence of oral cancer in India has resulted due to the prevalence of tobacco use both in smokable and Chewable forms. Though molecular level changes that occur in the initiation and progression of oral cancer has been studied, the disease process is still poorly understood unlike other cancers. MicroRNAs are the trending name in cancer research. They are non-coding RNAs that control the genome by their complementarity and affect protein synthesis. Their role in various cancers have been well studied. This paper enlightens the role of MicroRNA21 in oral cancer.
Highlights
Oral cancer is one among the leading causes of death in developing countries of south Asia
Oral squamous cell carcinoma(OSCC) is the most common type of oral cancer that affects the epithelial cells of the mucosa covering the oral cavity and presents with varying degrees of differentiation[2]
Though these RNAs do not code for any protein, they control protein synthesis by base pairing to the target mRNA thereby resulting in either translational repression or complete degradation of the mRNA itself
Summary
Oral cancer is one among the leading causes of death in developing countries of south Asia. Since cancer results due to the deregulation of the above mentioned cellular processes it can be well justified that microRNAs play a very significant role in both tumor initiation and progression as proven by various studies.
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