Abstract
Circular RNAs (circRNAs) are covalently closed circular structures without 5′ caps and 3′ tails, which are mainly formed from precursor mRNAs (pre-mRNAs) via back-splicing of exons. With the development of RNA sequencing and bioinformatic analysis, circRNAs were recently rediscovered and found to be widely expressed in the tree of life. Cerebellar degeneration-related protein 1 antisense RNA (CDR1as) is recognized as one of the most well-identified circRNAs. It contains over 70 miR-7 binding sites and can regulate gene activity by sponging miR-7. Increasing numbers of studies have recently demonstrated that CDR1as is abnormally expressed in many types of tumors, such as colorectal cancer, cholangiocarcinoma and osteosarcoma, and plays a vital role in the development of cancer. However, there are few reviews focusing on CDR1as and cancer. Hence, it is important to review and discuss the role of CDR1as in cancer. Here, we first review the main biological features of CDR1as. We then focus on the expression and roles of CDR1as in cancer. Finally, we summarize what is known on the role of CDR1as in cancer and discuss future prospects in this area of research.
Highlights
Circular RNAs are covalently closed circular structures without 5 caps and 3 tails, which are mainly formed from precursor mRNAs via the back-splicing of exons (Hansen et al, 2013a; Jeck et al, 2013; Memczak et al, 2013; Jeck and Sharpless, 2014; Lasda and Parker, 2014)
High Cerebellar degeneration-related protein 1 antisense RNA (CDR1as) expression was associated with worse clinicopathological characteristics, including the T status, N status, histological grade, TNM stage and distant metastasis in solid tumors, such as esophageal squamous cell carcinoma (ESCC), non–small cell lung cancer (NSCLC), colorectal cancer (CC), and hepatocellular carcinoma (Zou et al, 2020)
Numerous experiments have demonstrated that CDR1as might be an oncogene and promote cellular proliferation and cancer metastasis
Summary
Circular RNAs (circRNAs) are covalently closed circular structures without 5 caps and 3 tails, which are mainly formed from precursor mRNAs (pre-mRNAs) via the back-splicing of exons (Hansen et al, 2013a; Jeck et al, 2013; Memczak et al, 2013; Jeck and Sharpless, 2014; Lasda and Parker, 2014). There is increasing evidence that CDR1as can act as an miRNA sponge by absorbing several miRNAs (Shi et al, 2017; Kyei et al, 2020) Among these miRNAs, miR-7 functions as a tumor suppressor in many cancer types, such as osteosarcoma, breast cancer, hepatocellular carcinoma, and colorectal cancer (Yu et al, 2016; Tang et al, 2017; Yang X. et al, 2017; Xu et al, 2018). CDR1as was found to stimulate tube formation in microvascular endothelial cells by decreasing the expression of miR-26a-5p (Cui et al, 2020) Taken together, these studies demonstrate that CDR1as plays varied roles in the occurrence and development of cancer and might be a potential therapeutic target.
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