The emerging importance of NAD+ metabolome for nutrition and food sciences: A bibliometric analysis

Abstract

NAD+ is crucial for cellular balance in all organisms. Recent interest has focused on its metabolism. Deficiency-related issues can be countered using NMN and NR, potential therapies available through diet or supplementation. These compounds are emerging as nutraceuticals and bioactive food elements. Bibliometric analysis was used to study the scientific output and impact of research on the NAD+ metabolome. For this, the terms “nicotinamide adenine dinucleotide” or “NAD+” or “NAD+ precursors” or “nicotinamide riboside” or “nicotinamide mononucleotide” were searched in the topic title in The Web of Science™ database. Only original articles and articles review were considered. VOSviewer was used for constructing and visualizing the bibliometric networks maps. A total of 10,568 papers were published, with a consistent increase in the number of publications, especially over the last decade. Biochemistry molecular biology, biophysics, cell biology, chemistry multidisciplinary and microbiology were the top 5 field research in the subject. The majority of the publications came from the ‘Journal of biological chemistry’ and ‘Biochemistry’ journals. The prominent research topics included longevity, sirtuins, NAD+ precursors, oxidation and reduction reactions, enzymes, microbial biotechnology, cancer therapy, and crop science. Finally, a guide for future investigation in nutrition and food sciences areas was proposed, which holds immense potential for developing innovative strategies to enhance food quality, promote optimal nutrition, and explore new avenues for improving human health. To our knowledge, this is the first bibliometric analysis of NAD+ metabolome, which can provide valuable insights into the research landscape in this multidisciplinary rapidly growing field.