Proceedings of the Frontiers of Retrovirology Conference 2016

Abstract

Table of contentsOral presentationsSession 1: Entry & uncoatingO1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replicationIrena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk LindemannO2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infectionClaire Da Silva Santos, Kevin Tartour, Andrea CimarelliO3 Dynamics of nuclear envelope association and nuclear import of HIV-1 complexesRya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay PathakO4 Human papillomavirus protein E4 potently enhances the susceptibility to HIV infectionOliver T. KepplerSession 2: Reverse transcription & integrationO5 Structure and function of HIV-1 integrase post translational modificationsKarine Pradeau, Sylvia Eiler, Nicolas Levy, Sarah Lennon, Sarah Cianferani, Stéphane Emiliani, Marc RuffO6 Regulation of retroviral integration by RNA polymerase II associated factors and chromatin structureVincent ParissiSession 3: Transcription and latencyO7 A novel single-cell analysis pipeline to identify specific biomarkers of HIV permissivenessSylvie Rato, Antonio Rausell, Miguel Munoz, Amalio Telenti, Angela CiuffiO8 A capsid-dependent integration program linking T cell activation to HIV-1 gene expressionAlexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Janos Kriston-Vizi, Robin Ketteler, Chen-Hsuin Lee, Andy Merritt, Petronela Ancuta, Charles Bangham, Ariberto FassatiO9 Characterisation of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genomeAnthony Rodari, Benoit Van Driessche, Mathilde Galais, Nadége Delacourt, Sylvain Fauquenoy, Caroline Vanhulle, Anna Kula, Arsène Burny, Olivier Rohr, Carine Van LintO10 Tissue-specific dendritic cells differentially modulate latent HIV-1 reservoirsThijs van Montfort, Renee van der Sluis, Dave Speijer, Ben BerkhoutSession 4: RNA trafficking & packagingO11 A novel cis-acting element affecting HIV replicationBo Meng, Andrzej Rutkowski, Neil Berry, Lars Dölken, Andrew LeverO12 Tolerance of HIV’s late gene expression towards stepwise codon adaptationThomas Schuster, Benedikt Asbach, Ralf WagnerSession 5: Assembly & releaseO13 Importance of the tax-inducible actin-bundling protein fascin for transmission of human T cell leukemia virus Type 1 (HTLV-1)Christine Gross, Veit Wiesmann, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma-KressO14 Lentiviral nef proteins antagonize TIM-mediated inhibition of viral releaseMinghua Li, Eric O. Freed, Shan-Lu LiuSession 6: Pathogenesis & evolutionO15 SEVI and semen prolong the half-life of HIV-1Janis Müller, Jan MünchO16 CD169+ macrophages mediate retrovirus trans-infection of permissive lymphocytes to establish infection in vivoXaver Sewald, Pradeep Uchil, Mark Ladinsky, Jagadish Beloor, Ruoxi Pi, Christin Herrmann, Nasim Motamedi, Thomas Murooka, Michael Brehm, Dale Greiner, Thorsten Mempel, Pamela Bjorkman, Priti Kumar, Walther MothesO17 Efficient replication of a vpu containing SIVagm construct in African Green Monkeys requires an HIV-1 nef geneSimone Joas, Erica Parrish, Clement Wesley Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Ulrike Sauermann, Katharina Töpfer, Tina Schultheiss, Steven Bosinger, Guido Silvestri, Cristian Apetrei, Nicholas Huot, Michaela Müller-Trutwin, Daniel Sauter, Beatrice H. Hahn, Christiane Stahl-Hennig, Frank KirchhoffO18 Reprogramming initiates mobilization of endogenous mutagenic LINE-1, Alu and SVA retrotransposons in human induced pluripotent stem cells with consequences for host gene expressionGerald Schumann, Sabine Jung-Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Patricia Gerdes, Sylvia Merkert, Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, J. Garcia-Perez, Geoffrey J. FaulknerO19 NF-κB activation induces expression of human endogenous retrovirus and particle productionTara Hurst, Aris Katzourakis, Gkikas MagiorkinisSession 7a and b: Innate sensing & intrinsic immunityO20 Identification of the phosphatase acting on T592 in SAMHD1 during M/G1 transitionKerstin Schott, Rita Derua, Janna Seifried, Andreas Reuter, Heike Schmitz, Christiane Tondera, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Veerle Janssens, Renate KönigO21 Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cellsHanna-Mari Baldauf, Lena Stegmann, Sarah-Marie Schwarz, Maud Trotard, Margarethe Martin, Gina Lenzi, Manja Burggraf, Xiaoyu Pan, Oliver I. Fregoso, Efrem S. Lim, Libin Abraham, Elina Erikson, Laura Nguyen, Ina Ambiel, Frank Rutsch, Renate König, Baek Kim, Michael Emerman, Oliver T. Fackler, Oliver T. KepplerO22 The role of SAMHD1 in antiviral restriction and immune sensing in the mouseSabine Wittmann, Rayk Behrendt, Bianca Volkmann, Kristin Eissmann, Thomas GrambergO23 T cells expressing reduced restriction factors are preferentially infected in therapy naïve HIV-1 patientsSebastian Bolduan, Herwig Koppensteiner, Stefanie Regensburg, Ruth Brack-Werner, Rika Draenert, Michael SchindlerO24 cGAS-mediated innate immunity spreads through HIV-1 env-induced membrane fusion sites from infected to uninfected primary HIV-1 target cellsAurélie Ducroux, Shuting Xu, Aparna Ponnurangam, Sergej Franz, Angelina Malassa, Ellen Ewald, Christine GoffinetO25 Perturbation of innate RNA and DNA sensing by human T cell leukemia virus type 1 oncoproteinsSin-Yee Fung, Ching-Ping Chan, Chun-Kit Yuen, Kin-Hang Kok, Chin-Ping Chan, Dong-Yan JinO26 Induction and anti-viral activity of Interferon α subtypes in HIV-1 infectionUlf DittmerO27 Vpu-mediated counteraction of tetherin is a major determinant of HIV-1 interferon resistanceDorota Kmiec, Shilpa Iyer, Christina Stürzel, Daniel Sauter, Beatrice Hahn, Frank KirchhoffO28 DNA repair protein Rad18 restricts HIV-1 and LINE-1 life cycleYasuo Ariumi, Mariko Yasuda-Inoue, Koudai Kawano, Satoshi Tateishi, Priscilla TurelliO29 Natural mutations in IFITM3 allow escape from post-translational regulation and toggle antiviral specificityAlex Compton, Nicolas Roy, Françoise Porrot, Anne Billet, Nicoletta Casartelli, Jacob Yount, Chen Liang, Oliver SchwartzSession 8: Adaptive immunity & immune evasionO30 Observing evolution in HIV-1 infection: phylogenetics and mutant selection windows to infer the influence of the autologous antibody response on the viral quasispeciesCarsten Magnus, Lucia Reh, Penny Moore, Therese Uhr, Jacqueline Weber, Lynn Morris, Alexandra TrkolaO31 Dose and subtype specific analyses of the anti-HIV effects of IFN-alpha family members Rashel V. Grindberg, Erika Schlaepfer, Gideon Schreiber, Viviana Simon, Roberto F. SpeckSession 9: Novel antiviral strategiesO32 LEDGIN-mediated inhibition of the integrase-LEDGF/p75 interaction reduces reactivation of residual latent HIVZeger Debyser, Lenard Vranckx, Jonas Demeulemeester, Suha Saleh, Eric Verdin, Anna Cereseto, Frauke Christ, Rik GijsbersO33 NKG2D-mediated clearance of reactivated viral reservoirs by natural killer cellsO34 Inhibition of HIV reactivation in brain cells by AAV-mediated delivery of CRISPR/Cas9O35 CRISPR-Cas9 as antiviral: potent HIV-1 inhibition, but rapid virus escape and the subsequent design of escape-proof antiviral strategiesBen Berkhout, Gang Wang, Na Zhao, Atze T. DasSession 10: Recent advances in HIV vaccine developmentO36 Priming with a potent HIV-1 DNA vaccine frames the quality of T cell and antibody responses prior to a poxvirus and protein boostBenedikt Asbach, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L. Jacobs, David C. Montefiori, Celia C. LaBranche, Nicole L. Yates, Georgia D. Tomaras, Guido Ferrari, Kathryn E. Foulds, Mario Roederer, Gary Landucci, Donald N. Forthal, Michael S. Seaman, Natalie Hawkins, Steven G. Self, Sanjay Phogat, James Tartaglia, Susan W. Barnett, Brian Burke, Anthony D. Cristillo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Ralf WagnerO37 Passive immunisation with a neutralising antibody against HIV-1 Env prevents infection of the first cells in a mucosal challenge rhesus monkey modelChristiane Stahl-Hennig, Viktoria Stab, Armin Ensser, Ulrike Sauermann, Bettina Tippler, Dennis Burton, Matthias Tenbusch, Klaus ÜberlaO38 HIV antibody Fc-glycoforms drive B cell affinity maturationGalit Alter, Giuseppe Lofano, Anne-Sophie Dugast, Viraj Kulkarni, Todd SuscovichPoster presentationsTopic 1: Entry & uncoatingP1 Dynein light chain is required for murine leukemia virus infectionTatiana Opazo, Felipe Barraza, Diego Herrera, Andrea Garces, Tomas Schwenke, Diego Tapia, Jorge Cancino, Gloria ArriagadaP2 Peptide paratope mimics of the broadly neutralising HIV-1 antibody b12Christina Haußner, Dominik Damm, Anette Rohrhofer, Barbara Schmidt, Jutta EichlerP3 Investigating cellular pathways involved in the transmission of HIV-1 between dendritic cells and T cells using RNAi screening techniquesRebecca Midgley, James Wheeldon, Vincent PiguetP4 Co-receptor tropism in HIV-1, HIV-2 monotypic and dual infectionsPriyanka Khopkar, Megha Rohamare, Smita KulkarniP5 Characterisation of the role of CIB1 and CIB2 as HIV-1 helper factorsAna Godinho-Santos, Allan Hance, Joao Goncalves, Fabrizio MammanoP6 Buffering deleterious polymorphisms in the highly constrained C2 region of HIV-1 envelope by the flexible V3 domainRomain Gasser, Meriem Hamoudi, Martina Pellicciotta, Zhicheng Zhou, Clara Visdeloup, Philippe Colin, Martine Braibant, Bernard Lagane, Matteo NegroniP7 Entry inhibition of HERV-K(HML-2) by an Env-IgG fusion proteinJula Wamara, Norbert BannertTopic 2: Reverse transcription & integrationP8 The R263K/H51Y resistance substitutions in HIV integrase decreases levels of integrated HIV DNA over timeThibault Mesplede, Nathan Osman, Kaitlin Anstett, Jiaming Calvin Liang, Hanh Thi Pham, Mark WainbergP9 The Retrovirus Integration Database (RID)Wei Shao, Jigui Shan, Mary Kearney, Xiaolin Wu, Frank Maldarelli, John Mellors, Brian Luke, John Coffin, Stephen HughesP10 The small molecule 3G11 inhibits HIV-1 reverse transcriptionThomas Fricke, Silvana Opp, Caitlin Shepard, Dmitri Ivanov, Baek Kim, Jose Valle-Casuso, Felipe Diaz-GrifferoP11 Dual and opposite regulation of HIV-1 integration by hRAD51: impact on therapeutical approaches using homologous DNA repair modulatorsVincent ParissiP12 A flexible motif essential for integration by HIV-1 integraseMarine Kanja, Pierre Cappy, Matteo Negroni, Daniela LenerP13 Interaction between HIV-1 integrase and the host protein Ku70: identification of the binding site and study of the influence on integrase-proteasome interplayEkaterina Knyazhanskaya, Andrey Anisenko, Timofey Zatsepin, Marina GottikhP14 Normalisation based method for deep sequencing of somatic retroelement integrations in human genomeAlexander Komkov, Anastasia Minervina, Gaiaz Nugmanov, Vadim Nazarov, Konstantin Khodosevich, Ilgar Mamedov, Yuri LebedevTopic 3: Transcription and latencyP15 BCA2/RABRING7 restricts HIV-1 transcription by preventing the nuclear translocation of NF-κBMarta Colomer-Lluch, Ruth Serra-MorenoP16 MATR3 post-transcriptional regulation of HIV-1 transcription during latencyAmbra Sarracino, Anna Kula, Lavina Gharu, Alexander Pasternak, Carine Van Lint, Alessandro MarcelloP17 HIV-1 tat intersects the SUMO pathway to regulate HIV-1 promoter activityAnn Marie McCartin, Anurag Kulkarni, Valentin Le Douce, Virginie GautierP18 Conservation in HIV-1 Vpr guides tertiary gRNA folding and alternative splicingAnn Baeyens, Evelien Naessens, Anouk Van Nuffel, Karin Weening, Anne-Marie Reilly, Eva Claeys, Wim Trypsteen, Linos Vandekerckhove, Sven Eyckerman, Kris Gevaert, Bruno VerhasseltP19 The majority of reactivatable latent HIV are genetically distinctHoi Ping Mok, Nicholas Norton, Axel Fun, Jack Hirst, Mark Wills, Andrew LeverP20 Do mutations in the tat exonic splice enhancer contribute to HIV-1 latency?Nicholas Norton, Hoi Ping Mok, Jack Hirst, Andrew LeverP21 Culture-to-Ct: A fast and direct RT-qPCR HIV gene reactivation screening method using primary T cell cultureValentin Le Douce, Ann Marie McCartin, Virginie GautierP22 A novel approach to define populations of early silenced provirusesDalibor Miklik, Filip Senigl, Jiri HejnarTopic 4: RNA trafficking & packagingP23 Functional analysis of the structure and conformation of HIV-1 genome RNA DISJun-ichi Sakuragi, Sayuri Sakuragi, Masaru Yokoyama, Tatsuo Shioda, Hironori SatoP24 Regulation of foamy viral env splicing controls gag and pol expressionJochen Bodem, Rebecca Moschall, Sarah Denk, Steffen Erkelenz, Christian Schenk, Heiner SchaalTopic 5: Assembly & releaseP25 Transfer of HTLV-1 p8 to target T cells depends on VASP: a novel interaction partner of p8Norbert Donhauser, Ellen Socher, Sebastian Millen, Heinrich Sticht, Andrea K. Thoma-KressP26 COL4A1 and COL4A2 are novel HTLV-1 tax targets with a putative role in virus transmissionChristine Gross, Sebastian Millen, Melanie Mann, Klaus Überla, Andrea K. Thoma-KressP27 The C terminus of foamy virus gag protein is required for particle formation, and virus budding: starting assembly at the C terminus?Guochao Wei, Matthew J. Betts, Yang Liu, Timo Kehl, Robert B. Russell, Martin LöcheltP28 Generation of an antigen-capture ELISA and analysis of Rec and Staufen-1 effects on HERV-K(HML-2) virus particle productionOliver Hohn, Saeed Mostafa, Kirsten Hanke, Stephen Norley, Norbert BannertP29 Antagonism of BST-2/tetherin is a conserved function of primary HIV-2 Env glycoproteinsChia-Yen Chen, Masashi Shingai, Pedro Borrego, Nuno Taveira, Klaus StrebelP30 Mutations in the packaging signal region of the HIV-1 genome cause a late domain mutant phenotypeChris Hellmund, Bo Meng, Andrew LeverP31 p6 regulates membrane association of HIV-1 gagMelanie Friedrich, Friedrich Hahn, Christian Setz, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich SchubertTopic 6: Pathogenesis & evolutionP32 Molecular and structural basis of protein evolution during viral adaptationAya Khwaja, Meytal Galilee, Akram AlianP33 HIV-1 enhancement and neutralisation by soluble gp120 and its role for the selection of the R5-tropic “best fit”Birco Schwalbe, Heiko Hauser, Michael SchreiberP34 An insertion of seven amino acids in the Env cytoplasmic tail of Human Immunodeficiency Virus type 2 (HIV-2) selected during disease progression enhances viral replicationFrançois Dufrasne, Mara Lucchetti, Patrick Goubau, Jean RuelleP35 Cell-associated HIV-1 unspliced to multiply spliced RNA ratio at 12 weeks ART correlates with markers of immune activation and apoptosis and predicts the CD4 T-cell count at 96 weeks ARTMirte Scherpenisse, Ben Berkhout, Alexander PasternakP36 Faster progression in non-B subtype HIV-1-infected patients than Korean subclade of subtype B is accompanied by higher variation and no induction of gross deletion in non-B nef gene by Korean red ginseng treatmentYoung-Keol Cho, Jungeun Kim, Daeun JeongP37 Aberrant expression of ERVWE1 endogenous retrovirus and overexpression of TET dioxygenases are characteristic features of seminomaKaterina Trejbalova, Martina Benesova, Dana Kucerova, Zdenka Vernerova, Rachel Amouroux, Petra Hajkova, Jiri HejnarP38 Life history of the oldest lentivirus: characterisation of ELVgv integrations and the TRIM5 selection pattern in dermopteraDaniel Elleder, Tomas Hron, Helena Farkasova, Abinash Padhi, Jan PacesP39 Characterisation of a highly divergent endogenous retrovirus in the equine germ lineHenan Zhu, Robert Gifford, Pablo MurciaP40 The emergence of pandemic retroviral infection in small ruminantsMaria Luisa Carrozza, Anna-Maria Niewiadomska, Maurizio Mazzei, Mounir Abi-Said, Joseph Hughes, Stéphane Hué, Robert GiffordP41 Near full-length genome (NFLG) Characterisation of HIV-1 subtype B identified in South AfricaAdetayo Obasa, Graeme Jacobs, Susan EngelbrechtP42 Acquisition of Vpu-mediated tetherin antagonism by an HIV-1 group O strainKatharina Mack, Kathrin Starz, Daniel Sauter, Matthias Geyer, Frederic Bibollet-Ruche, Christina Stürzel, Marie Leoz, Jean Christophe Plantier, Beatrice H. Hahn, Frank KirchhoffP43 The human endogenous retrovirus type K is involved in cancer stem cell markers expression and in human melanoma malignancyAyele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Ilaria Bucci, Chiara Cipriani, Corrado Spadafora, Paolo Sinibaldi-Vallebona, Claudia MatteucciP44 Natural infection of Indian non-human primates by unique lentivirusesS. Nandi Jayashree, Ujjwal Neogi, Anil K. Chhangani, Shravan Sing Rathore, Bajrang R. J. MathurP45 Free cervical cancer screening among HIV-positive women receiving antiretroviral treatment in NigeriaAdeyemi AbatiP46 Molecular evolutionary status of feline immunodeficiency virus in TurkeyB. Taylan Koç, Tuba Çiğdem OğuzoğluTopic 7: Innate sensing & intrinsic immunityP47 Cell-to-cell contact with HTLV-1-infected T cells reduces dendritic cell immune functions and contributes to infection in trans.Takatoshi Shimauchi, Stephan Caucheteux, Jocelyn Turpin, Katja Finsterbusch, Charles Bangham, Yoshiki Tokura, Vincent PiguetP48 Deciphering the mechanisms of HIV-1 exacerbation induced by Mycobacterium tuberculosis in monocytes/macrophagesShanti Souriant, Luciana Balboa, Karine Pingris, Denise Kviatcowsky, Brigitte Raynaud-Messina, Céline Cougoule, Ingrid Mercier, Marcelo Kuroda, Pablo González-Montaner, Sandra Inwentarz, Eduardo Jose Moraña, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino, Christel VérolletP49 The SAMHD1-mediated inhibition of LINE-1 retroelements is regulated by phosphorylationAlexandra Herrmann, Sabine Wittmann, Caitlin Shepard, Dominique Thomas, Nerea Ferreirós Bouzas, Baek Kim, Thomas GrambergP50 Activities of nuclear envelope protein SUN2 in HIV infectionXavier Lahaye, Anvita Bhargava, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cécile Conrad, Hakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-François Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan King, Jean-Michel Pawlotsky, Nicolas ManelP51 Activation of TLR7/8 with a small molecule agonist induces a novel restriction to HIV-1 infection of monocytesHenning Hofmann, Benedicte Vanwalscappel, Nicolin Bloch, Nathaniel LandauP52 Steady state between the DNA polymerase and Rnase H domain activities of reverse transcriptases determines the sensitivity of retroviruses to inhibition by APOBEC3 proteinsStanislav Indik, Benedikt HagenP53 HIV restriction in mature dendritic cells is related to p21 induction and p21-mediated control of the dNTP pool and SAMHD1 activity.José Carlos Valle-Casuso, Awatef Allouch, Annie David, Françoise Barré-Sinoussi, Michaela Müller-Trutwin, Monsef Benkirane, Gianfranco Pancino, Asier Saez-CirionP54 IFITM protens restrict HIV-1 protein synthesisWing-Yiu Lee, Chen Liang, Richard SloanP55 Characterisation and functional analysis of the novel restriction factor Serinc5Bianca Schulte, Silvana Opp, Felipe Diaz-GrifferoP56 piRNA sequences are common in Human Endogenous Retroviral Sequences (HERVs): An antiretroviral restriction mechanism?Jonas Blomberg, Luana Vargiu, Patricia Rodriguez-Tomé, Enzo Tramontano, Göran SperberP57 Ferroportin restricts HIV-1 infection in sickle cell diseaseNamita Kumari, Tatiana Ammosova, Sharmeen Diaz, Patricia Oneal, Sergei NekhaiP58 APOBEC3G modulates the response to antiretroviral drugs in humanized miceAudrey Fahrny, Gustavo Gers-Huber, Annette Audigé, Roberto F. Speck, Anitha Jayaprakash, Ravi Sachidanandam, Matt Hernandez, Marsha Dillon-White, Viviana SimonP59 High-throughput epigenetic analysis of evolutionarily young endogenous retrovirus presents in the mule deer (Odocoileus hemionus) genomeTomas Hron, Helena Farkasova, Daniel EllederP60 Characterisation of the expression of novel endogenous retroviruses and immune interactions in a macaque modelNeil Berry, Emmanuel Maze, Claire Ham, Neil Almond, Greg Towers, Robert BelshawP61 HIV-1 restriction by orthologs of SERINC3 and SERINC5Patrícia de Sousa-Pereira, Joana Abrantes, Massimo Pizzato, Pedro J. Esteves, Oliver T. Fackler, Oliver T. Keppler, Hanna-Mari BaldaufP62 TRIM19/PML restricts HIV infection in a cell type-dependent mannerBianca Volkmann, Tanja Kahle, Kristin Eissmann, Alexandra Herrmann, Sven Schmitt, Sabine Wittmann, Laura Merkel, Nina Reuter, Thomas Stamminger, Thomas GrambergP63 Recent invasion of the mule deer genome by a retrovirusHelena Farkasova, Tomas Hron, Daniel EllederP64 Does the antiviral protein SAMHD1 influence mitochondrial function?Ilaria Dalla Rosa, Kate Bishop, Antonella Spinazzola, Harriet GroomP65 cGAMP transfers intercellularly via HIV-1 Env-mediated cell–cell fusion sites and triggers an innate immune response in primary target cellsShuting Xu, Aurélie Ducroux, Aparna Ponnurangam, Sergej Franz, Gabrielle Vieyres, Mathias Müsken, Thomas Zillinger, Angelina Malassa, Ellen Ewald, Veit Hornung, Winfried Barchet, Susanne Häussler, Thomas Pietschmann, Christine GoffinetP66 Pre-infection transcript levels of FAM26F in PBMCS inform about overall plasma viral load in acute and postacute phase after SIV-infectionUlrike Sauermann, Aneela Javed, Nicole Leuchte, Gabriela Salinas, Lennart Opitz, Christiane Stahl-Hennig, Sieghart SopperP67 Sequence-function analysis of three T cell receptors targeting the HIV-1 p17 epitope SLYNTVATLChristiane Mummert, Christian Hofmann, Angela G. Hückelhoven, Silke Bergmann, Sandra M. Müller-Schmucker, Ellen G. Harrer, Jan Dörrie, Niels Schaft, Thomas HarrerP68 An immunodominant region of the envelope glycoprotein of small ruminant lentiviruses may function as decoy antigenLaure Cardinaux, M.-L. Zahno, H.-R. Vogt, R. Zanoni, G. BertoniP69 Impact of immune activation, immune exhaustion, broadly neutralising antibodies and viral reservoirs on disease progression in HIV-infected childrenMaximilian Muenchhoff, Philip Goulder, Oliver KepplerTopic 9: Novel antiviral strategiesP70 Identification of natural compounds as new antiviral products by bioassay-guided fractionationAlexandra Herrmann, Stephanie Rebensburg, Markus Helfer, Michael Schindler, Ruth Brack-WernerP71 The PPARG antagonism disconnects the HIV replication and effector functions in Th17 cellsYuwei Zhang, Huicheng Chen, Delphine Planas, Annie Bernier, Annie Gosselin, Jean-Pierre Routy, Petronela AncutaP72 Characterisation of a multiresistant subtype AG reverse transcriptase: AZT resistance, sensitivity to RNase H inhibitors and inhibitor bindingBirgitta Wöhrl, Anna Schneider, Angela Corona, Imke Spöring, Mareike Jordan, Bernd Buchholz, Elias Maccioni, Roberto Di Santo, Jochen Bodem, Enzo Tramontano, Kristian SchweimerP73 Insigths into the acetylation pattern of HDAC inhibitors and their potential role in HIV therapyChristian Schölz, Brian Weinert, Sebastian Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars Jensen, Werner Streicher, Anna McCarthy, Nicholas Westwood, Sonia Lain, Jürgen Cox, Patrick Matthias, Matthias Mann, James Bradner, Chunaram ChoudharyP74 HPV-derived and seminal amyloid peptides enhance HIV-1 infection and impair the efficacy of broadly neutralising antibodies and antiretroviral drugsMarcel Stern, Oliver T. KepplerP75 D(−)lentiginosine inhibits both proliferation and virus expression in cells infected by HTLV-1 in vitroElena Valletta, Caterina Frezza, Claudia Matteucci, Francesca Marino-Merlo, Sandro Grelli, Anna Lucia Serafino, Antonio Mastino, Beatrice MacchiP76 HIV-1 resistance analyses of the Cape Winelands districts, South AfricaSello Mikasi, Graeme Jacobs, Susan EngelbrechtTopic 10: Recent advances in HIV vaccine developmentP77 Induction of complex retrovirus antigen-specific immune responses by adenovirus-based vectors depends on the order of vector administrationMeike Kaulfuß, Sonja Windmann, Wibke BayerP78 Direct impact of structural properties of HIV-1 Env on the regulation of the humoral immune responseRebecca Heß, Michael Storcksdieck gen. Bonsmann, Viktoria Stab, Carsten Kirschning, Bernd Lepenies, Matthias Tenbusch, Klaus ÜberlaP79 Lentiviral virus-like particles mediate gerenration of T-follicular helper cells in vitro Anne Kolenbrander, Klaus Überla, Vladimir TemchuraP80 Recruitment of HIV-1 Vpr to DNA damage sites and protection of proviral DNA from nuclease activityKenta Iijima, Junya Kobayashi, Yukihito Ishizaka