Abstract
To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.
Highlights
The 2009 influenza A(H1N1) pandemic virus emerged in Mexico in March 2009 and spread globally and uncontrollably during the following months
The emergence of oseltamivir-resistant seasonal influenza A(H1N1) viruses was first noted in Norway 2007 [3], and these resistant viruses have since evolved into the dominant influenza A(H1N1) seasonal viruses circulating in humans
Systematic follow-up of patients hospitalised with 2009 pandemic influenza and treated with oseltamivir and large-scale screening of untreated hospitalised 2009 pandemic influenza patients showed an association between the appearance of the H275Y mutation and oseltamivir treatment
Summary
The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, NovemberDecember, 2009. Citation style for this article: Citation style for this article: Harvala H, Gunson R, Simmonds P, Hardie A, Bennett S, Scott F, Roddie H, McKnight J, Walsh T, Rowney D, Clark A, Bremner J, Aitken C, Templeton K. To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. We identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir
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