Abstract
Uterine fibroids are benign tumors of the smooth muscles of the uterus that are the most common indication of hysterectomy in the America with over $34.4 billion annual cost. Risk factors include age, hypertension, diabetes, polycystic ovarian syndrome, black race, early age of menarche, nulliparity, obesity and a genetic factor comes in place.
Highlights
Leimyomas, known as myomas or uterine fibroids (UF), are benign tumors of the smooth muscles of the uterus
Aromatase inhibitors were compared to GnRH agonists in a randomized controlled, clinical trial and found to be more effective in reducing the size of UFs, and this was the only trial that fit the criteria for a 2013 cochrane review
Et al in 2011 demonstrated the possible mechanisms that vitamin D could reduce the size of the UFs, while simultaneously confirming that vitamin D could inhibit the growth of UF cells. human uterine leiomyoma (HuLM) were treated with vitamin D and the results compared with controls after 120 hours
Summary
Known as myomas or uterine fibroids (UF), are benign tumors of the smooth muscles of the uterus. Not originally intended to be used for the treatment of fibroids, some studies such as Kailasam, et al have reported good results with significant reduction in the size of the UFs [22,23]. The mechanism of action responsible for how cabergoline shrinks fibroids is unclear and it seems as though combining cabergoline with aromatase inhibitor did not make a significant change to the effects of reduction of the size of UFs [25].
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