Abstract
The tryptophan metabolism in rats after hypophysectomy or adrenalectomy has been studied. In animals kept on a complete diet there was a diminution of kynurenine and diazotizable substances after removal of one of the glands under consideration (the urinary concentrations of these metabolites reach normal values only after 19 days from hypophysectomy). Elimination of xanthurenic acid increases after hypophysectomy and decreases after adrenalectomy; in this latter case it is accompanied by an increase in nicotinic acid. In pyrixodine-deficient animals urinary elimination of kynurenine is lower after adrenalectomy; a supplement of pyridoxine restores it to normal.
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