Abstract
The observations of Delprat and others1 that an aqueous solution of rose bengal when injected intravenously into animals is rapidly eliminated through the bile, is not without theoretical significance as well as of practical value. Its behavior in this respect is wholly like that of the bile acids.2 Rose bengal is not soluble in the ordinary fat solvents and its behavior in the body does not follow the assumption of Mendel and Daniels3 that substances which are eliminated from the body by way of the bile must be insoluble in water and soluble in bile or substances contained therein.Rose bengal is a highly diffusible substance and it was not found possible to retain it within an ordinary collodion membrane. This property suggested that it might be possible by ligation of the bile duct to force the dye through the kidney. Numerous experiments∗ which were carried out on both dogs and rabbits showed that after ligation of the bile duct, rose bengal was found present in the blood stream for a period of 48 hour...
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