Abstract
AbstractPurposeTo determine the specific changes in the parameters of electroretinography (ERG), reflecting various aspects of retinal ganglion cell (GC) function, and optical coherence tomography (OCT), and their correlations in patients with advanced stages of primary open‐angle glaucoma (POAG).MethodsThe study included 35 people (55 eyes) with stages II and III POAG, divided into two subgroups, and 28 healthy age‐matched individuals (32 eyes). Transient and stationary pattern‐electroretinograms (PERG) and photopic negative response (PhNR) were recorded according to the ISCEV Standards (RETIport/scan, Roland Consult). The thickness of the GC complex (GCC) of the macular region was assessed (Heidelberg Spectralis OCT). The correlation analysis of the GCC indicators and the ERG data was performed. Validation for normal data distribution was performed using the Shapiro‐Wilk test. The Student's t‐test was used to compare normally distributed independent samples. Correlation analysis was performed using Pearson's correlation coefficient.ResultsWe found a reduction in the amplitude of N95 and P50 waves of transient PERG, the stationary PERG, PhNR, and PhNR/b index, and an increase in the peak latency of the N95 and P50 in both patient groups (p < 0.05). A statistically significant thinning of all layers of the GCC was noted in all the studied sectors (p < 0.01). The most essential morphological/functional correlations we determined between the amplitude of stationary PERG and the thickness of the GCC (r > 0.8; p < 0.01). The results showed moderate correlation relationships between parameters of the transient PERG and GCC (r > 0.4; p < 0.01) and between the PhNR amplitude and GCC thickness (r > 0.5; p < 0.01).ConclusionsWe documented specific changes in the morphological and functional parameters of the inner retina in patients with advanced stages of POAG. The detected regularities can be used as clinical markers of the disease and monitor the efficiency of a chosen therapeutic strategy.
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