Abstract

Using vesicles from the plasma membrane of hog thyroid, we have characterized its Na +-dependent I − transport system. We have found it to be totally Na + dependent; K + cannot substitute and Li + can partially substitute for Na +; the Na +:I − flux ratio is larger than one; the system is electrogenic, being stimulated by a Δψ negative inside the vesicles. A number of large, lipophilic anions are fully-competitive inhibitors of Na +-dependent I − uptake; the closer their atomic radii are to that of iodine, the smaller their K i values.

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