The electrochemical behavior and oxidation mechanism of sertraline on a rutin modified electrode

Abstract

A rutin-modified glassy carbon electrode (R/GCE), which showed electro-catalytic capability for the oxidation of sertraline, was prepared by electrochemically bonding. The modification mechanism and electrochemical behavior of the R/GCE were systematically investigated. It was found that the hydroxyl groups on GCE which bonded with rutin acted as a Michael receptor by a nucleophilic reaction. The immobilized rutin molecules undertook a reversible 2e/2H+ redox, which contributed to a catalytic oxidation of sertraline. The oxidation mechanism of sertraline on R/GCE was investigated by infrared spectrum (IR) and electrochemical techniques. It was found that the catalytic oxidation of sertraline on R/GCE was an irreversible 2e/2H+ redox. Sertraline was detected using a differential pulse voltammetry method. The oxidation current of sertraline linearly related to its concentration in the range of 3.0–90.0μM with a detection limit of 1.0μM (S/N=3). The content of sertraline in Zoloft tablets was also detected to validate the applicability of proposed modified electrode.