Abstract

Contrast-enhanced ultrasound (CEUS) was originally introduced to enhance Doppler signals of macrovessels. With the introduction of sulphur hexafluoride (SonoVue ®), real time low mechanical index (MI) contrast-enhanced ultrasound was introduced to analyse the microvascularity. Because of their physical size (at or smaller than red blood cells), ultrasound contrast agents (UCAs) act as pure blood pool agents which explains some of the advantages of CEUS.

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