Abstract
Multidisciplinary techniques, in particular the combination of theoretical and experimental immunology, can address questions about human immunity that cannot be answered by other means. From the turnover of virus-infected cells in vivo, to rates of thymic production and HLA class I epitope prediction, theoretical techniques provide a unique insight to supplement experimental approaches. Here we present our opinion, with examples, of some of the ways in which mathematics has contributed in our field of interest: the efficiency of the human CD8+ T cell response to persistent viruses.
Highlights
We all carry lifelong, persistent viral infections
More than 70% of adults are infected with Epstein Barr Virus (EBV), 80%–90% with Cytomegalovirus, and .90% with Varicella Zoster Virus
170 million people are infected with Hepatitis C virus (HCV) and 33 million with Human Immunodeficiency Virus (HIV-1)
Summary
Persistent viral infections. More than 70% of adults are infected with Epstein Barr Virus (EBV), 80%–90% with Cytomegalovirus, and .90% with Varicella Zoster Virus. Two types of experimental data have been used to quantify CD8+ T cell efficiency in humans in vivo, both in the context of HIV-1 infection.
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