The Efficiency of First Trimester Screening Test: A Retrospective Study in a Referral Center in Turkey

Abstract

Objective: To investigate the effectivity of first trimester screening test applied in in a referral center in Ankara, Turkey. Materials and Methods: The records of 2015 patients who underwent the first trimester screening test between January 2016 and December 2017 were retrospectively screened. We did not take the patients who does not postpartum newborn examination, whose pregnancies resulted as abortion and who did not sustain the routine pregnancy control visits. Invasive diagnostic test was recommended to patients who has high-risk test results. Amniocentesis was applied to the patients who accepted the procedure. We reached the newborn examination results of the patients who did not have amniocentesis result. Amniocentesis was recorded with the patient's new registrar record. Sensitivity, specificity, positive predictive value and negative predictive value were calculated according to biochemical and combined risks respectively. Results: According to the combined risk of first trimester screening test, the sensitivity was 80%, specificity was 95.9%, positive predictive value was 6,25% and negative predictive value was 99,9%. Sensitivity was determined as 60%, specificity 88.6%, positive predictive value 1.7% and negative predictive value 99.9% according to biochemical risk. Conclusions: The first trimester screening test is an effective prenatal test for the detection of chromosomal anomalies. Adding NT measurement to biochemical parameters increases the efficiency of the test significantly.