Abstract
Osteoarthritis (OA) is one of the leading causes of disability in the elder population. OA is a chronic disorder characterized by joint pain and inflammation, increasing physical disability and continuous cartilage degeneration.The changes of lubricating properties of synovial fluid lead to significant pain and loss of function. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable treatment. The injection of hyaluronic acid in the joints, improves the biochemical properties of synovial fluid into osteoarthritis of knee joints. The clinical effect is pain relief and disease modifying activity. Hyaluronic acid is a relatively new treatment that has shown varied results through several clinical trials. It can be used as a scaffold for engineering new treatments and several new preparations have been just added to the markets.
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