The efficacy of Xuebijing injection combined with Ulinastatin for acute pancreatitis: a Meta analysis

Abstract

Objevtive To investigate the efficacy of Xuebijing injection combined with Ulinastatin for acute pancreatitis. Methods Databases were searched, like Pubmed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Cochrane library, and Wangfang for randomized controlled trial (RCT) about the treatment of Xuebijing injection combined with Ulinastatin for acute pancreatitis. After evaluating the quality of literatures objectively, data were analyzed by RevMan 5.0 software. we evaluated abdominal pain relief time, recovery time of blood amylase, recovery time of white blood cell (WBC), concentration of interleukin (IL)-6, IL-8, tumor necrosis factor -α (TNF-α) and total effective rate. Results Eleven studies and 893 patients were accepted into this article. Meta-analysis showed that abdominal pain relief time [weighted mean difference (WMD)=-1.71, 95% CI: -2.21, -1.21, P<0.01], recovery time of blood amylase (WMD=-1.82, 95% CI: -2.39, -1.25, P<0.01), recovery time of WBC (WMD=-2.75, 95% CI: -3.19, -2.31, P<0.01), and hospital stay time (WMD=-5.99, 95% CI: -7.73, -4.26, P<0.01) in experimental group was better than control group. Compared to control group, on the seventh day after treatment, inflammatory cytokines, including IL-6 [standardized mean difference (SMD)=-1.09, 95% CI: -2.66, 0.48, P=0.17], IL-8 (SMD=-1.02, 95% CI: -1.66, -0.38, P<0.01), and TNF-α (SMD=-1.10, 95% CI: -1.68, -0.53, P<0.01) were lower. In experimental group, total effective rate was better than the control group (RR=1.16, 95% CI: 1.07, 1.25, P=0.0002). Conclusions Xuebijing injection combined with Ulinastatin for acute pancreatitis was more effective than traditional basal treatment or using Ulinastatin alone. However, the literature quality were mediocre, we need more large, random, double blind, and polycentric clinical study to prove further. Key words: Glycoproteins/AD; Drugs, chinese herbal/AD; Pancreatitis/ZJ; Meta-analysis