The efficacy of triple and quadruple therapy for thetreatment of peptic ulcer disease

Abstract

This study was designed to determine the efficacy of triple and quadruple therapy for the treatment of peptic ulcer disease. Seventy five patients underwent Helicobacter Pylori associated peptic ulcer ,as determined by endoscopy and rapid urease test of biopsy were paiiicipated in this study. They were divided to 4 groups. Three of them were treated with triple therapy. The triple therapy in the first group consisted of omprazole 20 mg BID + amoxicillin 500 mg QID + metronidazole 500 mg TID . For the second group , only omprazole was replaced by ranitidine 150 mg BID , while for the third group metronidazole was replaced by clarithromycin 500mg BID . All triple therapies were given for 2 weeks. However , for the fourth group , a quadruple therapy consisted of omprazole 20mg BID + amoxicillin 500mg QID + clarithromycin 500mg BID + metronidazole 500mg TID , was given for one week. The efficacy in the four groups, was 91.3, 88.89, 90, and 100% respectively. All treatmentregimens were well tolerated and no sever side effects necessitated cessation of the treatment.