The Efficacy of Tricholoroacetic Acid 70% after Microneedling in the Treatment of Non-Segmental Vitiligo.

Abstract

AbstractIntroduction: Vitiligo is a common disorder characterized by progressive depigmentation of the skin due to selective destruction of melanocytes. Although its cause is still to be exactly defined, the hypothesis of an autoimmune etiology is supported by increasing evidence.Objective: To assess the efficacy of TCA 70% after skin microneedling using dermapen in the treatment of non segmental vitiligo.Patients and Methods: This current study was conducted on 34 patients of both sexes at outpatient clinic of Dermatology, Venereology and Andrology Department at Zagazig University during the period from January 2018 to November 2018. A written informed consent was taken from each patient after explaining to them the details about the nature of study and after obtaining approval from Institutional Review Board (IRB).IRB approval number is (4587).The patients received 4 sessions of microneedling followed by TCA 70% at 2 weeks interval, followed up monthly for 3 monthsResults:Evaluation of repigmentation by the qualitative method showed that the improvement was good to excellent (repigmentation >50%) in 53% of patients, the improvement was moderate (26-50%) in 14.8% of patients, there was no effect in 8.2% of patients. Conclusion: Microneedling plus TCA 70% is considered a simple modality to treat vitiligo of all age groups with cosmetically acceptable repigmentation and a relatively safe alternative or additive method that can be used prior to (or in conjunction with) any of the well-known and widely approved treatment modalities of stable, non-segmental vitiligo.