The Efficacy of Platelets Rich Plasma (PRP) for Ovarian Rejuvenation

Abstract

Background: In recent years, an increased approach has appeared in the use of autologous blood products to assist tissue and organ healing. Application of PRP has emerged as a potential solution for infertile women with poor ovarian reserve in reproductive specialty. Objective: To estimate the efficacy of trans-vaginal ovarian injection with PRP in rejuvenation of ovaries in woman with poor ovarian reserve. Methods: A stratified, non-randomized, Before-After comparison clinical trial. It was performed in the High Institute for Infertility Diagnosis, and Baghdad fertility center from August 2018 to May 2019. 50 Infertile women of different age group with poor ovarian reserve were included. For each patient, autologous PRP preparation was done and it was injected to both ovaries under ultrasound (US) guidance. Outcome measures: hormones tests was measured before and after four weeks of intervention to monitor ovarian reserve tests. Before and after Follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH), antral follicles count (AFC), and mean ovarian volume (MOV) in different categories for variables. Results: Infertile women showed a significant improvement of instead of ovarian reserve tests after PRP injection. A reduction in FSH level, an increase in AMH level, with an increase in AFC, and mean ovarian volume, were observed. Conclusions: 4 weeks after PRP injection for ovarian rejuvenation had favorable effects in women with poor ovarian reserve, opening an opportunity window in management of infertility.