The Efficacy of Montelukast in Adjunct with Amoxicillin in Treatment of Acute Otitis Media (AOM) in Children

Abstract

BackgroundAcute otitis media (AOM) is very common in children. In spite of spontaneously relief, some cases suffer from the recurrence and other complications occurring after AOM. Animal studies have proved that persistence of leukotrienes in the middle ear may play a role in the development of AOM. Based on this statement, treatment with leukotriene modifiers may be effective in the treatment of OM. The aim of this study was to examine the effect of adjunction of to antibacterial agents in treatment of AOM.Materials and MethodsOne hundred patients aged 2-6 years were randomly divided into two groups. One of the groups (53%) were treated with alone, 80-90 mg/kg amoxicillin for 10 days, and the other group (47%), received and montelukast 5 mg per day orally for 10 days. Patients were evaluated for resolution and complications of AOM at 2 post enrollment visits (days 2-4 and 10-14).ResultsThe patient followed-up for one month and results showed that, treatment with had beneficial effects on resolution of AOM. In monotherapy (amoxicillin alone) group, 66% of patients and in the (amoxicillin and montelukast) group, 85.1% were treated.ConclusionIn this study, the receiving group showed a better response to treatment. Based on this and previous studies, it is recommended to consider the role of inflammatory mediators in AOM. Prescribing and other leukotriene receptor antagonists may have benefits for the patients.