Abstract
Objective: Treatment of arterial hypertension reduces cardiovascular mortality and morbidity. Currently, the majority of patients during the treatment does not reach the target blood pressure (BP). One common cause of reaching the target pressure is poor adherence to treatment, which can improve the use of fixed combination therapy. The aim of our work is to analyze the effect on office blood pressure and influence of the number of antihypertensive medications deployment of fixed triple combination therapy (perindopril/indapamide/amlodipine) Design and method: We enrolled 194 patients (122 men, average age 63.9 years). All patients underwent a clinical examination and office blood pressure measurements. It was subsequently modified antihypertensive therapy according to current guidelines ESH/ESC using a fixed combination of perindopril/indapamide/amlodipine. The effect of changes in therapy was evaluate the next clinical control, with an average interval of 15 weeks. Results: Mean baseline office BP values were 168.9 ± 22.1/87.9 ± 12.6 mmHg. Patients received treatment prior to the change was averaged 3.9 ± 1.4 antihypertensive drugs, which represented 3.3 ± 2.0 daily tablet antihypertensive drugs. After adjusting treatment insignificantly increased the number of daily used antihypertensive agent by 0.2 ± 1.0 (p = 0.099) and significantly reduced the number of antihypertensive tablets per day 1.2 ± 1.4 (p < 0.001). Systolic blood pressure after changing average decreased by 23.6 ± 3.7 mmHg (p < 0.001) and diastolic blood pressure by 9.7 ± 2.3 mmHg (p < 0.001). The average office blood pressure achieved after treatment therapies were 132.7/83.0 mmHg. Conclusions: The use of fixed triple combination therapy of arterial hypertension significantly reduced systolic and diastolic office blood pressure. At the same time there is a significant decrease in the number of antihypertensive tablets per day, which probably contributes to better adherence to treatment.
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