The efficacy of different types of heparin in intra-aortic balloon counterpulsation

Abstract

Objective To explore the efficacy of low molecular weight heparin versus that of unfractionated heparin in intra-aortic balloon counterpulsation.Methods 28 patients who received low-molecular-weight heparin during intra-aortic balloon counterpulsation were assigned to study group,while 30 patients who received unfractionated heparin were allocated to control group.The efficacy was compared between the two groups.Results The immediate improvement rate of disease severity and the mortality rate within 30 days did not differ significantly between the two groups [(67.86％ vs.56.67％) and (10.71％ vs.16.67％),(P＞ 0.05)].The incidence rate of complications including bleeding and hematoma was significantly lower in the study group than in the control group (7.14％ vs.30％),with a relative risk ratio of 4.200.There were no significant differences in the incidence of plug formation in balloon center and that of lower limb ischemia between the two groups (3.57％ vs.16.67％).The mean platelet count was lower in the control group than in the study group [(158.5 ± 82.9) × 109/L vs.(231.3 ± 45.2) × 109/L].Conclusions During intra-aortic balloon counterpulsation,as compared with unfractionated heparin,although low-molecular-weight heparin has no marked effect on disease severity and rate of mortality,it significantly lowers the rate of bleeding and has less impact on platelet.Low-molecular-weight heparin can replace unfractionated heparin as an anticoagulant during intra-aortic balloon counterpulsation. Key words: Aortic balloon pump surgery; Unfractionated heparin; Low-molecular-weight heparin; Efficacy