Abstract
Background: Deep brain stimulation (DBS) is a promising adjuvant therapy for Parkinson’s disease (PD) in intermediate and advanced states, improving motor symptoms and life quality. Objectives: To investigate the efficacy of DBS in PD treatment. Design and Setting: Systematic review performed on medical school in Brazil. Methods: A literature review in the MedLine database was conducted using the following descriptors: “Deep Brain Stimulation”, “Parkinson’s Disease” and its variations according to MeSH. Only randomized controlled trials conducted in humans and published in English in the last 10 years were included. The PRISMA statement was used to improve this systematic review’s findings. Results: Three clinical trials that evaluated the effects of DBS in PD’s management were analysed. The main result measurement tools used in the studies were the PDQ-39-SI and UPDRS-III scores. Hacked ML et al. (2018) concluded that drug therapy + DBS was significantly superior to isolated drug therapy (p <0.0002). Schuepbach WMM et al. (2019) found that the experimental group presented significantly better outcomes in comparison to the control group (p <0,05). Birchall EL et al. (2016) suggested that the DBS device implant in the subthalamic nucleus caused significant improvement in depressive symptoms, motor symptoms, quality of sleep (p <0.0001) and quality of life (p=0.0005) in comparison to the control group. Conclusions: DBS has shown to be an efficient therapy for PD, once it promoted better outcomes regarding motor symptoms, depression, quality of life and quality of sleep. However, it is necessary to be aware of eventual side effects in the post-operative period.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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