Abstract
Methods Thirty studies with 1308 eyes were identified and included in this study. The primary outcome measures were best-corrected visual acuity (BCVA), and secondary outcomes were optical coherence tomography characteristics and polyp regression rates. The pooled results were calculated by the random-effect or fixed-effect model according to the heterogeneity of the data. Results Despite a large standard deviation in means (SMD) improvement for BCVA and central retinal thickness (CRT) in the conbercept group, there was no statistically significant difference in the other outcomes compared to ranibizumab and aflibercept. However, there was a greater polyp regression rate in the conbercept group at 12 months. Conclusions This systematic review indicates that conbercept may achieve similar BCVA and CRT improvements as ranibizumab and aflibercept, with a superior rate of polyp regression at 12 months.
Highlights
Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration defined by orange-red bulb-like lesions and characteristic polypoidal features with or without a branching vascular network (BVN) on imaging [1, 2]. It was first described as posterior uveal bleeding syndrome [3] later described by Yannuzzi et al as a choroidal vasculopathy which led to hemorrhage and exudation in 1990 [4]. It differs from typical choroidal neovascularization (CNV) in nAMD by the presence of serous or hemorrhagic pigment epithelial detachment (PED) which can cause serous retinal detachment or submacular hemorrhage leading to severe visual deterioration [5]
A PubMed, EMBASE, Clinical Trial, Web of Science, Cochrane Library, and Wanfang Database search using the search terms “polypoidal choroidal vasculopathy” or “PCV” and “vascular endothelial growth factor,” “anti-VEGF,” “ranibizumab,” “Lucentis,” “aflibercept,” “Elyea,” “conbercept,” or “Lumitin” was performed. e search did not have a limitation of language
In studies comparing anti-VEGF monotherapy and PDT monotherapy, only data related to anti-VEGF monotherapy was included in our study
Summary
Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (nAMD) defined by orange-red bulb-like lesions and characteristic polypoidal features with or without a branching vascular network (BVN) on imaging [1, 2]. It was first described as posterior uveal bleeding syndrome [3] later described by Yannuzzi et al as a choroidal vasculopathy which led to hemorrhage and exudation in 1990 [4]. It is critical and common to use the polyp regression rate as a parameter in the studies to evaluate the outcome of PCV [7, 9]
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