The efficacy of Conbercept assisted vitrectomy for severe proliferative diabetic retinopathy

Abstract

Objective To observe the clinical efficacy of 23G microinvasive vitrectomy assisted by intravitreal injection of Conbercept for severe proliferative diabetic retinopathy. Methods A retrospective analysis data of medical material of 43 eyes of 39 cases with severe proliferative diabetic retinopathy treated with 23G vitrectomy assisted by intravitreal injection of Conbercep was performed. The best corrected visual acuity (BCVA)and the central macular thickness(CMT) were compared pre-postoperative with 1 week, 1 month, 3 months and 6 months postoperatively. The pre-postoperative intraocular pressure was measured, and the operative time and other operative results were recorded. Results In 6 months follow-up, BCVA and CMT were different in 1 week, 1 month, the difference was statistically significant (P 0.05). The average operation time was (65.21±17.01)min, Three eyes occurred higher postoperatively intraocular pressure, 2 eyes occurred iatrogenic retinal hole, 2 eyes were filled with silicone oil or gas, and retinal reattachment was observed in 41 eyes, which accounted for 6.97%, 4.62%, 4.62% and 95.35%, respectively. There were no postoperative bleeding in the period of follow-up. Conclusion The vitrectomy assisted by intravitreal injection of Conbercept is effective. But the improvement of BCVA and CMT postoperative 6 months will be further explored. Key words: Diabetic retinopathy, proliferative, severe; Conbercept, intravitreal injection; Vitrectomy