Abstract
A total of 57 infants hospitalized with rotavirus disease were included in this study. The children were randomly divided into the study’s two treatment groups: three days of the oral administration of (i) a probiotics formula containing both Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 (N = 28); or (ii) a placebo (probiotic-free skim milk, N = 29) and the standard therapy for diarrhea. There were no differences in age, sex, or blood characteristics between the two groups. When the 57 cases completed the protocol, the duration of the patients’ diarrhea was significantly shorter in the probiotics group (4.38 ± 1.29, N = 28) than the placebo group (5.61 ± 1.23, N = 29), with a p-value of 0.001. Symptoms such as duration of fever (p = 0.119), frequency of diarrhea (p = 0.119), and frequency of vomiting (p = 0.331) tended to be ameliorated by the probiotic treatment; however, differences were not statistically significant between the two groups. There were no serious, adverse events and no differences in the frequency of adverse events in both groups.
Highlights
Diarrhea-associated deaths in children under five years old in developing countries have been a major cause of childhood mortality [1]
All patients were recruited and classified from the inpatient Department of Pediatrics at Yonsei University Hospital in Seoul, Korea. This double-blind, randomized, and placebo-controlled clinical study tests the efficacy of probiotics formula to ameliorate the pathological symptoms in children hospitalized with rotavirus infections
A total of 57 infants hospitalized with rotavirus infection were enrolled in this study. patients were assigned to the probiotics treatment group, and the remaining patients were assigned to the placebo group
Summary
Diarrhea-associated deaths in children under five years old in developing countries have been a major cause of childhood mortality [1]. These illnesses are caused by multiple factors, including infections by pathogenic microorganisms, viruses, and parasites [2]. Global reports show that most babies and toddlers are infected with rotavirus by the age of five [4]. This causes serious problems in developing and/or low-income countries (e.g., South Asian and sub-Saharan African countries), and hundreds of thousands of babies are killed by rotavirus annually [5]. Supported therapeutic methods that are compatible with common rotavirus medical treatments and effectively relieve its symptoms should be developed
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