The efficacy of ampicillin vs. cephalosporins in the treatment of community adquire pneumonia in inpatient children hospital III Grau

Abstract

Introduction Community adquire pneumonia CAP is one of the most serious diseases in the childhood It is necessary to choose the correct antibiotic Bacterial resistance complicates the therapy and makes it necessary to use new antibiotics so young doctors have poor experience to use penicillin Objective To compare clinical effectiveness of ampicillin to st and rd generation cephalosporin in the treatment of community adquire pneumonia in inpatient children Patients and methods Descriptive retrospective study included children inpatient in Emergencias Grau Hospital III Essalud Lima Per uacute from months to years old from July to July Clinical variables of antibiotic groups were compared Effectiveness was analyzed with Kaplan Meier curves ndash Log Rank method Survival to treatment was determined by time between starting and change of antibiotic Results children were included were under one year old were diagnosed as bronchopneumonia and acute bronchial obstructive syndrome ABOS and CAP Antibiotics ampicillin cefazolin ceftriaxone and claritromycin Statistically significant results favored ampicillin more indicated in under one year old p respiratory distress shorter p and recovering faster p There was no significant difference at comparing the need for antibiotic change when using ampicillin cefazolin and ceftriaxone It did show difference when compared to other antibiotics p Conclusion ampicillin is as effective as cefazolin or ceftriaxone for the treatment of CAP in children It is suggested to follow the antibiotic ladder to rationalize antibiotics and to avoid bacterial resistance