Abstract
In China, lung cancer is one of the leading causes of death among residents. Early diagnosis is of great significance for early interventional treatment and prolonging survival. PET/CT uses positron radiopharmaceuticals to observe the physiological and biochemical changes of the drug and its metabolites in the body and finally diagnoses the disease. 18F-FDG is a commonly used imaging agent, but its short isotopic half-life limits clinical high-throughput testing. This study retrospectively analyzed the imaging material of 100 lung cancer patients pathologically confirmed. Patients with lymph node metastasis were classified into the LM group (n = 30 cases), and those with no lymph node metastasis were classified into the NLM group (n = 70 cases). The results showed that MRI of superparamagnetic nanoferric oxide was better than diagnosis of lung cancer by the 18F-FDG PET/CT and had a high predictive power for lymph node metastasis. These turned out to be high-value lung cancer diagnosis of superparamagnetic nanoferric oxide MRI and high-capacity lymph node metastasis prediction of 18F-FDG PET/CT, which were worthy of implementation.
Highlights
As a malignant tumor whose primary focus is located in the bronchial mucosal epithelium, lung cancer has the highest mortality and morbidity among cancer diseases, threatening the health and life of patients [1, 2]
Contrast agents are used in the process of Magnetic resonance imaging (MRI) detection to enhance the contrast effect of images
We found superparamagnetic nanoferric oxide MRI and 18F-FDG PET/CT had high value in diagnosis of lung cancer
Summary
As a malignant tumor whose primary focus is located in the bronchial mucosal epithelium, lung cancer has the highest mortality and morbidity among cancer diseases, threatening the health and life of patients [1, 2]. 18F-FDG is a commonly used metabolic imaging agent labeled by fluorine 18, which can track the metabolic process of glucose in lung tumors, detect the activity and location of lung tumors, and make an effective differential diagnosis of lung cancer [5]. This diagnostic method is highly sensitive and quantifiable, the short half-life of 18FFDG isotope limits clinical high-throughput testing, and the presence of 18F-FDG radioactivity can cause toxicity to the patient’s organs. This study explored the efficacy of N-SUVmax, T-SUVmax, T-MTV, T-TLG, and other parameters of 18F-FDG PET/CT in predicting lymph node metastasis, and the data and results of the study were reported in detail below
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