The efficacy and toxicity of mirvetuximab soravtansine, a novel antibody-drug conjugate, in the treatment of advanced or recurrent ovarian cancer: a meta-analysis

Abstract

ABSTRACT Introduction This meta-analysis aims to systematically analyze the efficacy and toxicity of mirvetuximab soravtansine (MIRV) as second-line and above treatment for advanced or recurrent ovarian cancer. Methods Candidate studies were identified in PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases up to 1 May 2023. Objective response rate (ORR), progression-free survival (PFS), the incidence of adverse events (AEs), and incidence of grade ≥ 3 AEs were extracted and calculated by meta-analysis of merging ratios or mean to describe the efficacy and toxicity of MIRV. Results Seven eligible prospective studies were included in this meta-analysis, including 605 patients with advanced ovarian cancer who received second-line or higher therapy. ORR of MIRV was 34.2% (95% confidence interval [CI] 25.0–43.5), and PFS was 5.82 months (95%CI 4.47–7.18). The overall incidence of AEs was 87.4% (95%CI 52.9–100.0) and the incidence of grade ≥ 3 AEs was 27.1% (95%CI 18.9–36.1). The most common AEs were vision blurring, nausea, and diarrhea, with incidence of 46.7% (39.6–53.8), 41.8% (34.0–49.9), and 41.3% (30.4–52.5), respectively. Conclusions MIRV has definite efficacy and good safety as a novel choice for second-line and above treatment of advanced or recurrent FRα positive ovarian cancer. This may have promising application in patients with platinum-resistant diseases. PROSPERO registration number CRD42023428599