Abstract
Background:Cerebral infarction is a commonly dangerous disease also with high morbidity and mortality. Thrombolytic agent is an effective method to treat it, but their relative efficacy and safety are unclear. A network meta-analysis (NMA) will be conducted to resolve this urgent problem.Methods:The PubMed, Embase, and Cochrane library will be systematically search from their inception to November 2018. All randomized controlled trials (RCTs) will be included this NMA and their risk of bias will be assessed using Cochrane handbook tool. The outcomes of efficacy and safety including: Modified Rankin Scale scores, reperfusion rate, incidence of symptomatic intracerebral hemorrhage and all-cause mortality. A network meta-analysis will be performed using R x64 3.5.1 software and pairwise meta-analysis will be conducted using Stata 12.0 software (Stata Corp., College Station, Texas). Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess quality of outcomes.Results:The results of NMA will be published in a peer-reviewed journal.Conclusion:The NMA will provide a comprehensive evidence summary on thrombolytic agents for patients with cerebral infarction.
Highlights
Cerebral infarction is a commonly dangerous disease with high morbidity and mortality.[1]
It is estimated that about 5.5 million people die from cerebral infarction annually around the Ethics and dissemination: Ethical approval and patient consent are not required since this study is a network meta-analysis based on published studies
Randomized controlled trials (RCTs) that compared the effect of different thrombolytic agents for patients with cerebral infarction will be included in this network meta-analysis (NMA)
Summary
The PubMed, Embase, and Cochrane library will be systematically search from their inception to November 2018. All randomized controlled trials (RCTs) will be included this NMA and their risk of bias will be assessed using Cochrane handbook tool. The outcomes of efficacy and safety including: Modified Rankin Scale scores, reperfusion rate, incidence of symptomatic intracerebral hemorrhage and all-cause mortality. A network meta-analysis will be performed using R x64 3.5.1 software and pairwise meta-analysis will be conducted using Stata 12.0 software (Stata Corp., College Station, Texas). Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess quality of outcomes
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