Abstract
The degradation of structural collagen contributes to the characteristic appearance of wrinkles. The anti-wrinkle effects of a variety of substances have been studied, but the potential anti-wrinkle effects of topical applications of collagen for periorbital wrinkles have not been investigated. To evaluate the effects of topical application of succinylated atelocollagen on periorbital wrinkles and to compare the results of treatment with adenosine, a clinical study on Korean participants was carried out. Each participant’s right or left periorbital area was treated with either a solution containing succinylated atelocollagen and adenosine or a solution containing only succinylated atelocollagen for two months. A placebo solution was applied to the opposite periorbital area of each patient’s face for two months. Based on objective and subjective measurements of clinical improvement, the assessment scores for treated sites were statistically significantly higher than scores for placebo sites after two months of treatment. Analysis of silicone casts of periorbital wrinkles demonstrated partial effects of succinylated atelocollagen on periorbital wrinkles. However, we did not observe any effects of adenosine on periorbital wrinkles. Succinylated atelocollagen may be an effective treatment option for periorbital wrinkles, but further studies including a longer treatment period and larger subject group are needed to verify these results.
Highlights
Skin aging manifests as changes in skin thickness, color, elasticity, vascular dilatation and wrinkles
We did not observe any effects of adenosine on periorbital wrinkles
Activated receptors and growth factors stimulate transcription factor AP-1 through a signal transduction cascade, and AP-1 stimulates the transcription of matrix metalloproteinase (MMP) genes
Summary
Skin aging manifests as changes in skin thickness, color, elasticity, vascular dilatation and wrinkles. Epidermal atrophy and the degeneration of dermal collagen and elastic fibers lead to the formation of wrinkles and fine lines. Sunlight, smoking and pollutants increase the production of collagenase, and an enzyme breaks down collagen through a signal transduction cascade, resulting in the acceleration of wrinkle formation [2]. In the field of dermatology, there is increasing demand for effective, convenient medications and cosmetics that prevent or treat wrinkles and that have few side effects. Studies on a variety of agents that may be effective for treating and preventing wrinkles are ongoing, with retinoids, vitamin C and adenosine considered especially effective [1]. The potential anti-wrinkle effects of topical applications of collagen, a component of the dermis, have not been investigated
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