Abstract
Objective. To determine the efficacy and safety of direct-acting antiviral agents (DAA) in patients with chronic HCV infection and UGT1A1*28 polymorphism. Materials and Methods. An open-label, non-randomized, observational study to assess efficacy and safety of DAA in patients (n = 143) with chronic hepatitis C (CHC) and liver cirrhosis and UGT1A1*28 polymorphism was performed. A total of 139 patients with chronic HCV infection were included in the efficacy analysis (absence of HCV RNA in blood by PCR) by the rate of sustained virologic response at week 12 (SVR12). Results. The SVR12 rate in patients with CHC and HCV-CP was 92.5% and 87.9%, respectively (p = 0.508), regardless of the presence of UGT1A1*28 polymorphism. The SVR12 rate in patients with chronic HCV infection and (TA)7/(TA)7 was 84.8%, with (TA)6/(TA)7 – 92.2% compared with (TA)6/ (TA)6 – 90,5% (p = 0.518). The rate of SVR12 in patients with CHC and (TA)7/(TA)7 or (TA)6/(TA)7 was 80% and 95%, respectively, with (TA)6/(TA)6 – 95.2%. The rate of SVR12 in patients with liver cirrhosis and (TA)7/(TA)7 or (TA)6/(TA)7 was 92.3% and 87.5%, respectively, with (TA)6/(TA)6 – 85.7%. The rate of SVR12 in patients with 12- and 24-week treatment duration was 88.2% and 96.6%, respectively (p = 0.30). As many as 96.2% of patients with the previous treatment with interferon and ribavirin had SVR12 compared to 88.5% of patients who have not previously taken antiviral drugs (p = 0.486). Grade 1 adverse events (AE) occurred in 24% of patients with chronic HCV infection treated with DAA; two patients developed Grade 4 AE. Conclusions. The treatment with DAA was shown to be effective and safe in patients with chronic HCV infection and UGT1A1*28 polymorphism.
Highlights
Подписные индексы По каталогу «Журналы Рос сии» на 2020 г. агентства «Роспечать»: 82125 – для индивидуальных подписчиков; 82126 – для организаций
The study has been approved by the local ethics committee
Grade 1 adverse events (AE) occurred in 24% of patients with chronic HCV infection treated with direct-acting antiviral agents (DAA); two patients developed Grade 4 AE
Summary
Зырянов С.К., Голуб А.В., Козлов Р.С. 21 Доксициклин в современной клинической практике. 30 Применение хлоргексидина для профилактики госпитальных инфекций в отделениях реанимации и интенсивной терапии: современное состояние проблемы. Иванчик Н.В., Сухорукова М.В., Чагарян А.Н., Дехнич А.В., Козлов Р.С., Андреев В.А., Беккер Г.Г., Варганова А.Н., Гудкова Л.В., Ершова М.Г., Жолобова А.Ф., Зубарева Н.А., Исхакова Л.М., Кириллова Г.Ш., Кречикова О.И., Лазарева А.В., Морозова О.А., Москвитина Е.Н., Наговицина С.Г., Петрова Т.А., Рахманова О.А., Сало Е.А, Чернявская Ю.Л., Яранцева Н.З. 40 Антибиотикорезистентность клинических штаммов Streptococcus pyogenes в России: результаты многоцентрового эпидемиологического исследования «ПеГАС 2014–2017». Божкова С.А., Гордина Е.М., Шнейдер О.В., Рукина А.Н., Шабанова В.В. 47 Резистентность продуцирующих карбапенемазы штаммов Klebsiella pneumoniae, выделенных от пациентов с ортопедической инфекцией. 53 Опыт использования онлайн-платформы AMRcloud для ветеринарного мониторинга антибиотикорезистентности зоонозных бактерий Макаров Д.А., Карабанов С.Ю., Крылова Е.А., Поболелова Ю.И., Иванова О.Е., Гергель М.А., Куликовский А.В., Сухоедова А.В. 53 Опыт использования онлайн-платформы AMRcloud для ветеринарного мониторинга антибиотикорезистентности зоонозных бактерий
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