Abstract
Background and objectiveBowel preparation (BP) is a major determinant of accurate and successful colonoscopy and its outcomes in children and adults. The present study aimed to evaluate the effectiveness and safety of a senna alkaloid and probiotic-based BP in children undergoing elective colonoscopy.MethodsChildren aged 2-15 years who underwent esophagogastroduodenoscopy (OGD) and colonoscopy for various indications from December 2018 to May 2019 at the Apollo Children’s Hospital who were prescribed a senna and probiotic-based [Bacillus coagulans (B. coagulans)] preparation before the procedure were included in the study. The effectiveness of the bowel preparation was assessed using the Boston Bowel Preparation Scale (BBPS). Safety assessment was performed by recording adverse events in the study.ResultsSuccessful bowel preparation was observed in all patients according to BBPS, and the mean BBPS score was 2.93 ±0.25, indicating good bowel clearance. About 29 (96.67%) patients showed accessible terminal ileum. There were no major side effects reported in the study. The formulation was found to be palatable and acceptable by 100% of patients.ConclusionThe study revealed the administration of the novel BP to be effective and safe in children undergoing elective colonoscopy for various indications.
Highlights
Colonoscopy is essential for the diagnosis and management of various gastrointestinal (GI) tract disorders and is presently the standard investigation for assessing the mucosa of the entire colon
Our study primarily aims to add to the current evidence for the effectiveness and safety of this first-of-itskind combination, M Sip Lax® straws consisting of a probiotic (B. coagulans SNZ1969) and senna alkaloid for clearing the bowel in Indian pediatric patients with various gastrointestinal complaints that require a colonoscopy
We showed that the bowel preparation (BP) agent consisting of a probiotic ( B. coagulans SNZ1969) and senna alkaloid-based formulation was safe and effective in pediatric patients in our cohort who underwent OGD and colonoscopy
Summary
Colonoscopy is essential for the diagnosis and management of various gastrointestinal (GI) tract disorders and is presently the standard investigation for assessing the mucosa of the entire colon. Children usually undergo the procedure for diagnostic purposes for indications such as GI bleeding, abdominal pain, and diarrhea, and/or any other indication based on the discretion of the clinician [1]. The procedure should be accurate and safe. The accuracy and safety of the procedure are highly dependent on colon cleansing, i.e., bowel preparation (BP). An ideal BP agent should be effective, safe, tolerable, and should have a high compliance rate [4]. Bowel preparation (BP) is a major determinant of accurate and successful colonoscopy and its outcomes in children and adults. The present study aimed to evaluate the effectiveness and safety of a senna alkaloid and probiotic-based BP in children undergoing elective colonoscopy
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