Abstract
Objective To observe the effects of Yishen-Pinggan dcoction on the urine microalbumin and the expression of ACE2, AngⅡin the spontaneously hypertensive rat kidney（SHR）;to observe the kidney level hepatic side of the protective effect of early renal in SHR hypertension. Methods The same old male SHR and normal rats（Wistar-Kyoto rats, WKY） for the study, at 10 weeks of age, SHR rats were randomly divided into a model group, a Chinese medicine group, and a lotensin group;while WKY rats were served as a normal control group（n=8）. They were continuously treated for 12 weeks. Urine mAlb and β2-MG of rats were quantified at pre-experiment and after experiment, immuno-histochemical detection of renal ACE2 and AngⅡwere performed, the obtained results were statistically analyzed by computer image analysis. Result At the 12th week, compared with urinary mAlb（509.3±160.3）ng/ml,β2-MG（0.150±0.037）μg/ml, Ang kidneyⅡ（7 174.24±1 068.99）μm2,kidney ACE2（2 158.90±376.60）μm2 in the WKY group, the urinary mAlb（908.3 ±13.2）ng/ml, β2-MG（0.378±0.099）μg/ml, kidney AngⅡ（11 085.37±1 398.03）μm2 in the hypertension model group were significantly higher（P〈0.01）, and kidney ACE2（1 375.77±466.21）μm2 was decreased significantly（P〈0.01）; compared with hypertensive model group, rat urinary mAlb（574.9±197.8）ng/ml,β2-MG（0.198±0.040）μg/ml, kidney AngⅡ（8 462.91±781.23）μm2 in Chinese medicine group, rat urinary mAlb（644.4±147.5）ng/ml, β2-MG（0.206±0.044）μg/ml, kidney AngⅡ（8 696.88±679.70）μm2 in lotensin group were significantly decreased（P〈0.01）; while kidney ACE2（1 904.02 ± 454.08）μm2 in Chinese medicine group, kidney ACE2（1896.11±445.43）μm2 in lotensin group was significantly increased（P〈0.01）.＆amp;nbsp;Conclusion Yishen-Pinggan decoction can reduce the SHR urinary microalbumin excretion so as to reduce high blood pressure early kidney damage; its role may be associated with its increasing local renal ACE2 expression and reducing the kidney Ang Ⅱ expression. Key words: Yishen-Pinggan decoction; Hypertension; Early renal damage; Ang II
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