Abstract
Objective To study the effects of Xuling-Jiangu formula on bone mineral density and the bone biomechanic in the osteoporosis model rats. Methods According to the random number table method, 40 SD female rats were randomly divided into the caltrate D group, the Xuling-Jianguformula group, the model group and the sham group,10 rats each group. In addition to the sham group, the other groups were osteoporosis model. After 30 days, the Caltrate D group received intragastric caltrate D mixed suspension 0.126 g/kg; the Xuling-Jiangu formula group received Xuling-Jianguformula solution 15 g/kg, and the sham group and the model group received normal saline 10 ml/kg. After 12 weeks treatment, detection of left tibia bone mineral density andthree-point bending method was used for biomechanical testing. Results The mineral density of the Xuling-Jiangu formula group (0.244±0.022 g/cm2,0.195±0.017 g/cm2vs. 0.223±0.013 g/cm2) were significantly higher than the model group and caltrate D group (P<0.01); compared with the model group, the bone biomechanictests in the Xuling-Jiangu formula group (0.072±0.036 kNvs.0.041±0.015 kN; 843.754±428.722 N/mm2vs. 482.084±176.646 N/mm2) were significantly higher (P<0.05). Conclusion Xuling-Jiangu formula canimprove the bone mineral density and the bone lbiomechanic of osteoporosis rats. Key words: Osteoporosis; Xuling-Jiangu formula; Bone density; Bone biomechanic; Rats
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