The Effects of Wolbiga-banha-tang on Obese Rats Fed a High-fat Diet

Abstract

This study investigated the effects of Wolbiga-banha-tang (WBBT) on high fat diet-induced rats. We divided the rats into 4 groups: normal (fed a general-fat diet), control (fed a high-fat diet and no treatment), WBBT×1 (fed a high-fat diet and 250 mg/kg of Wolbiga-banha-tang extracts), and WBBT×2 (fed a high-fat diet and 500 mg/kg of Wolbiga-banha-tang extracts). We measured the body weight, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, free fatty acids, total lipids, AST, ALT, and CBC in the serum of the obese rats for 7 weeks. There was a significant decrease in the control group, WBBT×1, and WBBT×2 in triglycerides and free fatty acids. The results suggest that WBBT is effective for lowering triglycerides and free fatty acids. Therefore, WBBT may be applied to the treatment of lipid metabolism in obesity and further clinical studies are needed. Keywords: obesity, triglyceride, free fatty acid, Wolbiga-banha-tang (WBBT)