Abstract
Summary. Using in vitro cultures of mouse bone marrow cells, levels of colony stimulating factor were assayed in serum from mice following whole body irradiation. No significant differences from control levels were noted in the period 1–32 days following 50, 150, 250 or 450 rads. A dose of 250 rads caused a sharp fall in the level of colony‐forming cells in the bone marrow followed by regeneration between 6 and 16 days following irradiation.Six to 8 hours following whole body irradiation, blood polymorphs and serum colony stimulating factor levels were consistently elevated. Splenectomy did not affect this response.The results suggest that serum colony stimulating factor is unlikely to be the major regulator determining regeneration of in vitro colony‐forming cells in the bone marrow following irradiation.
Published Version
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