Abstract
Abstract Objective Conflicting data are available in literature regarding the effects of vitamin D (VitD) supplementation diet on lipid panel. Therefore, we had the purpose to evaluate the effects of VitD supplementation on lipid panel by a controlled experimental study, and those of VitD supplementation on oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemic male rabbits. Methods Thirty New Zealand rabbits were randomly separated into control, VD, HC+VD and HC groups. Control and VD groups were fed with standard chow, whereas HC+VD and HC groups were fed with 0.5% cholesterol chow a period of 8 weeks. During this period, VD and HC+VD groups were orally administered with 300 IU/kg/day VitD. Results The increase in serum total cholesterol (TC) and OSI level of HC group were significant compared to those in HC+VD group. Decreases in serum HDL-cholesterol (HDL-C) and TC levels of VD group were significant within the groups. Conclusion Without any doubt it is important that applied VitD level should be in the ideal range for healthy living. However, it is also necessary to increase the serum HDL-C level (and hence PON1), which is decreases as a result of VitD supplementation. Therefore, we believe that during VitD supplementation, regular physical activity should be performed to increases serum HDL-C.
Highlights
It is generally accepted that VitD deficiency is a worldwide health problem that affects musculoskeletal550 Rahim Kocabaş and Mehmet Aköz: The effects of vitamin D supplementation on healthy health and a wide range of acute and chronic diseases
We had the purpose to evaluate the effects of VitD supplementation on lipid panel by a controlled experimental study, and those of VitD supplementation on oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemic male rabbits
This study aimed to evaluate the effects of VitD supplementation on TAS, TOS, OSI, MDA and PON1 values in healthy and hypercholesterolemic male rabbits
Summary
Conflicting data are available in literature regarding the effects of vitamin D (VitD) supplementation diet on lipid panel. We had the purpose to evaluate the effects of VitD supplementation on lipid panel by a controlled experimental study, and those of VitD supplementation on oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemic male rabbits. Results: The increase in serum total cholesterol (TC) and OSI level of HC group were significant compared to those in HC + VD group. It is necessary to increase the serum HDL-C level (and PON1), which is decreases as a result of VitD supplementation. Bu yüzden projemizde kontrollü deneysel bir çalışma ile, sağlıklı ve hiperkolesterolemik erkek tavşanlara VitD ilavesinin lipit paneli üzerine etkisine, ve yine VitD ilavesinin oksidatif stress indeksi (OSI) ve paraoksonaz-1 (PON-1) değerleri üzerine etkilerini araştırmayı amaçladık. Anahtar Kelimeler: D vitamini; Paraoksonaz-1; Oksidatif Stres İndeksi; HDL Kolesterol; Hiperkolesterolemi; Tavşan
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