The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase

Abstract

Abstract Objective Conflicting data are available in literature regarding the effects of vitamin D (VitD) supplementation diet on lipid panel. Therefore, we had the purpose to evaluate the effects of VitD supplementation on lipid panel by a controlled experimental study, and those of VitD supplementation on oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemic male rabbits. Methods Thirty New Zealand rabbits were randomly separated into control, VD, HC+VD and HC groups. Control and VD groups were fed with standard chow, whereas HC+VD and HC groups were fed with 0.5% cholesterol chow a period of 8 weeks. During this period, VD and HC+VD groups were orally administered with 300 IU/kg/day VitD. Results The increase in serum total cholesterol (TC) and OSI level of HC group were significant compared to those in HC+VD group. Decreases in serum HDL-cholesterol (HDL-C) and TC levels of VD group were significant within the groups. Conclusion Without any doubt it is important that applied VitD level should be in the ideal range for healthy living. However, it is also necessary to increase the serum HDL-C level (and hence PON1), which is decreases as a result of VitD supplementation. Therefore, we believe that during VitD supplementation, regular physical activity should be performed to increases serum HDL-C.