The Effects of Vitamin D Supplement on Prevention of Preeclampsia in Pregnant Women

Abstract

Objective: To evaluate the role of vitamin D supplementation in preventing preeclampsia in pregnant women. Study Design: Randomized controlled trial. Place and Duration: The study was conducted in the Gynecology Department of Nishtar Hospital, Multan, from 1st January 2022 to 31 December 2022. Methodology: A total of 250 (N) pregnant patients with a history of prior pre-eclampsia were enrolled after taking informed consent. Patients in the control group were given a placebo, and in the intervention group, a vitamin-D supplement of 50000 IU after every two weeks was given. Primary variables of the study were systolic and diastolic blood pressure, proteinuria in 24 hours urine, termination of pregnancy results like cesarean section, spontaneous vaginal delivery or abortion, and development of preeclampsia. Results: In the intervention group, 62.4% of females had expected vaginal delivery, 33.6% had a cesarean section, and 4.0% had an abortion. Whereas 49.6% of females had a normal vaginal delivery, 45.6% had a cesarean section, and 4.8% had an abortion in the control group, which was statistically insignificant. The patients in the intervention group have significantly lower 23 (18.4%) presentation of preeclampsia than patients in the control group 31 (24.8%) (p<0.001), which is statistically significant. Conclusion: Vitamin D supplementation during pregnancy helps prevent preeclampsia and gestational hypertension recurrence. Keywords: Vitamin D, Preeclampsia, Gestational Hypertension, Proteinuria, Pregnant Women. How to Cite This: Ashraf S, Khosa AF, Fatima K, Ibrahim M. The Effects of Vitamin D Supplement on Prevention of Preeclampsia in Pregnant Women. Isra Med J. 2023; 15(1): 11-14. DOI: https://doi.org/10.55282/imj.oa1370 This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.