Abstract
BackgroundAttempts to use virtual reality (VR) as a treatment for various psychiatric disorders have been made recently, and many researchers have identified the effects of VR in psychiatric disorders. Studies have reported that VR therapy is effective in social anxiety disorder (SAD). However, there is no prior study on the neural correlates of VR therapy in patients with SAD.ObjectiveThe aim of this study is to find the neural correlates of VR therapy by evaluating the treatment effectiveness of VR in patients with SAD using portable functional near-infrared spectroscopy (fNIRS).MethodsPatients with SAD (n=28) were provided with 6 sessions of VR treatment that was developed for exposure to social situations with a recording system of each participant’s self-introduction in VR. After each VR treatment session, the first-person view (video 1) and third-person view (video 2) clips of the participant’s self-introduction were automatically generated. The functional activities of prefrontal regions were measured by fNIRS while watching videos 1 and 2 with a cognitive task, before and after whole VR treatment sessions, and after the first session of VR treatment. We compared the data of fNIRS between patients with SAD and healthy controls (HCs; n=27).ResultsWe found that reduction in activities of the right frontopolar prefrontal cortex (FPPFC) in HCs was greater than in the SAD group at baseline (t=–2.01, P=.049). Comparing the frontal cortex activation before and after VR treatment sessions in the SAD group showed significant differences in activities of the FPPFC (right: t=–2.93, P<.001; left: t=–2.25, P=.03) and the orbitofrontal cortex (OFC) (right: t=–2.10, P=.045; left: t=–2.21, P=.04) while watching video 2.ConclusionsActivities of the FPPFC and OFC were associated with symptom reduction after VR treatment for SAD. Our study findings might provide a clue to understanding the mechanisms underlying VR treatment for SAD.Trial RegistrationClinical Research Information Service (CRIS) KCT0003854; https://tinyurl.com/559jp2kp
Highlights
Social anxiety disorder (SAD) is a common psychiatric disease, with 8.4%-15% of the population worldwide diagnosed with it [1]
We found that reduction in activities of the right frontopolar prefrontal cortex (FPPFC) in healthy controls (HCs) was greater than in the social anxiety disorder (SAD) group at baseline (t=–2.01, P=.049)
Activities of the FPPFC and orbitofrontal cortex (OFC) were associated with symptom reduction after virtual reality (VR) treatment for SAD
Summary
Social anxiety disorder (SAD) is a common psychiatric disease, with 8.4%-15% of the population worldwide diagnosed with it [1]. Effective pharmacological agents for SAD treatment include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, benzodiazepines, and beta-adrenergic antagonists Nonpharmacological therapies, such as cognitive behavior therapy (CBT) or social skill training, and a combination of pharmacological and nonpharmacological therapies are considered treatment modalities [6,7,8]. These treatments are effective, patients with SAD may be reluctant to receive psychiatric medication, have difficulty in visiting the treatment room, and drop out of treatment to avoid social situations or spatial constraints. There is no prior study on the neural correlates of VR therapy in patients with SAD
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