Abstract
Electron microscopy was performed on normal human ureteral rings before and after incubation in human urine for 30 minutes. A large number of mast cells was detected subepithelially and in close proximity to smooth muscle fibres. Treatment with urine (346 mOsm/l) induced various degrees of degranulation in the majority of mast cells. Some membrane bound granules were found free in the surrounding connective tissue and near smooth muscle cells indicating rupture of the cell membrane. In the functional study frequency and amplitude of peristaltic contractions were studied in-vitro. Addition of urine increased frequency and amplitude of peristaltic contractions and addition of the histamine-1-blocker mepyramine (10(-6) M) partially reversed these changes. It can be concluded that in a situation with urothelial damage such as ureteral calculus, urine can penetrate subepithelially and induce degranulation of mast cells with release of mediators. This is followed by forceful peristaltic contractions which are induced by histamine and other newly formed mediators such as prostaglandins. The process is likely to occur in renal colic with impacted kidney stones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
