Abstract
胰性脑病是重症急性胰腺炎(SAP)的严重并发症,与大脑的毛细血管渗漏紧密相关.occludin蛋白是脑组织重要的紧密连接蛋白,与大脑毛细血管通透性密切相关.乌司他丁(UTI)是一种广谱的蛋白酶抑制剂,已经广泛用于临床,但其对胰性脑病的治疗及机制研究甚少.本研究旨在探讨occludin在SAP大脑毛细血管渗漏中的作用及UTI治疗胰性脑病的作用机制。
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