Abstract
BackgroundThe optimum dosage for vitamin D supplementation has not yet been elucidated in patients with Ulcerative colitis (UC). The aim of this study was to investigate the effects of two vitamin D regimens in UC patients with vitamin D deficiency.MethodsIn this double blind randomized clinical trial, 50 patients with mild to moderate UC, who met inclusion criteria, received either 1000 or 2000 IU/day of vitamin D (as low dose or high dose group, respectively) for 12 weeks. Serum 25-hydroxy vitamin D (25-OHD) level, total antioxidant capacity (TAC), and Total Oxidant Status (TOS), the inflammatory bowel disease questionnaire − 9 (IBDQ-9) score and the Simple Clinical Colitis Activity Index Questionnaire (SCCAI) score were assessed before and after intervention.ResultsAt the end of study, serum 25-OHD levels significantly increased in the high dose group (P < 0.001) and the increase was significantly more than low dose group (6.7 ± 3.8 ng/mL in the high dose group versus 0.2 ± 0.5 ng/mL in the low dose group) (P < 0.001). Serum TOS concentration decreased significantly (− 0.37 ± 0.26) only in the high dose group (P value = 0.023). There was no statistically significant change in serum TAC between two groups during the study. IBDQ-9 mean score significantly increased in high dose group compared to the low dose group (P value = 0.001) and SCCAI score in both groups reduced (− 2.58 ± 2.16 and − 0.9 ± 0.3 in high dose and low dose respectively), while this reduction was significant only in the high dose group (P value ≥0.001).ConclusionOur results indicate that 2000 IU daily dose of vitamin D can increase serum 25-OHD concentration, and quality of life, while it reduces disease activity in UC patients with vitamin D deficiency. We recommend assessment of the vitamin D status in all patients with UC because they may benefit from vitamin D therapy.
Highlights
Inflammatory bowel disease (IBD) is a type of immune-mediated chronic bowel disorder including Ulcerative colitis (UC) and Crohn’s disease (CD) [1]
To our knowledge, this study is the first double blind randomized clinical trial in adult patients with UC, which has assessed the effects of two dosages of vitamin D supplementation on its serum concentration, disease activity index, quality of life and body oxidative stress status
Our results have shown that daily dose of 2000 International units (IU) vitamin D increases 25-OHD level significantly; this result in daily dose of 1000 IU was not observed
Summary
Inflammatory bowel disease (IBD) is a type of immune-mediated chronic bowel disorder including Ulcerative colitis (UC) and Crohn’s disease (CD) [1]. The incidence and prevalence of IBD is increasing over time in western countries and in different parts of the world [9]. Little epidemiological information of developing countries is available, recent studies indicate that this disease is rapidly increasing in many developing countries as well as Africa, South America and Asia [9,10,11]. The optimum dosage for vitamin D supplementation has not yet been elucidated in patients with Ulcerative colitis (UC). The aim of this study was to investigate the effects of two vitamin D regimens in UC patients with vitamin D deficiency
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