Abstract
We investigated the effects of two novel copper-based inorganic formulations for their activity against 60 isolates of Helicobacter pylori (Hp). The two copper-based formulations were tested against three NCTC Helicobacter pylori isolates and 57 clinical strains isolated from the UK and Italy in time-kill assays. Both copper-based formulations were bio-cidal against all Helicobacter pylori strains tested reducing the viable count by 4–5 log within 2 h. These two copper-based anti-microbial agents deserve further study in relation to the treatment of H. pylori-related gastric disease.
Highlights
Helicobacter pylori is a gram negative, microaerophilic bacterium found principally in the stomach [1]
This regimen is advocated in the European Helicobacter Study Group (EHSG) Maastricht
We have investigated the efficacy of novel highly reductive copper compounds for their bactericidal activity against Helicobacter pylori
Summary
Helicobacter pylori is a gram negative, microaerophilic bacterium found principally in the stomach [1]. (1) Increasing antibiotic resistance; (2) Decreasing eradication rates from >90% to ~70%; (3) The need to take lots of tablets and compliance problems leading to antibiotic resistance and failure of eradication; (4) The association of proton pump inhibitor use with Clostridium difficile colitis [17]. For these reason potential alternative treatments have been investigated such as inhibition of binding [18], photodynamic therapy [19], biocidal action of spices [20], anti-malarial drugs [21], essential oils [22]. We have investigated the efficacy of novel highly reductive copper compounds for their bactericidal activity against Helicobacter pylori
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