The effects of trolamine cream on preventing skin-reaction of nasopharyngeal cancer patients with radiotherapy

Abstract

Objective To observe the effects of trolamine cream(biafine) on preventing nasopharyngeal cancer patients' radioactive skin-reaction after radiotherapy.Methods 110 nasopharyngeal cancer patients who use the linear accelerator radiotherapy were divided into the treatment group and the control group stochastically,the treatment group after the first radiotherapy was given trolamine cream to paint the irradiated coverage of skin,the control group only was given conventional nursing without any medicine.Observes two groups when 20 Gy,50 Gy,the 70 Gy dose the skin-reaction degree,and carries on the contrastive analysis.Results Treatment group and control group when 20 Gy dose,the skin-reaction rate is not remarkable difference,there is no statistical significance( x2 =6.25,P ＞ 0.05 ) ; While 50 Gy dose,the treatment group skin-reaction responds with degree Ⅰ (67.27％),control group with degree Ⅱ (45.45％),besides,14 degree Ⅲ skin reactions were occurred,there is significantly different( x2 =16.37,P ＜0.01 ) ; When 70 Gy,treatment group still with Ⅰand Ⅱ degree (81.82％),control group 70.90％ with Ⅲ degree,and 4 examples are forced to stop treatment because of the most serious skin reaction.To compare with control group,the skin-reaction of treatment group is obviously eased and deferred ( x2 =20.57,P ＜ 0.01 ).Conclusions Biafine can prevent skin-reaction of nasopharyngeal cancer patients' radioactive skin-reaction after radiotherapy,ease the patient' s pain,and make sure radiotherapy go on. Key words: Nasopharyngeal neoplasms; Radiotherapy; Radioactive skin-reaction; Trolamine cream