Abstract
Rats were given intraventricular injections of triethylcholine and hemicholinium-3 in order to impair brain acetylcholine synthesis. The effect of this procedure on the intensity of tremors produced by tremorine, eserine and harmine was determined together with the changes in brain acetylcholine content. Both triethylcholine and hemicholinium-3 prevented the increases in brain acetylcholine previously shown to be associated with tremorine and eserine administration and also antagonized the tremors produced by these two drugs. Harmine tremors however were not affected. It is concluded that the tremors produced by tremorine and eserine are probably associated with increased levels of free acetylcholine in the central nervous system.
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