Abstract
SUMMARY The uptake of 131I by the thyroid gland increased 72 hr. after the injection of pregnant mare serum gonadotrophin (PMS) into immature female rats whether ovulation occurred or not. PMS failed to produce this effect in male rats but oestrogen administration increased 131I uptake in both male and female immature rats, suggesting that oestrogen was responsible for the effect of PMS in females. Both PMS and oestrogen may increase the uptake of radioactive phosphate by the thyroid of female but not male rats; oestrogen may stimulate thyroid-stimulating hormone (TSH) secretion in immature female rats. These effects of oestrogen in the female made it impossible to determine whether the 'ovulatory surge' in luteinizing hormone secretion in PMS-treated rats was associated with an increased secretion of TSH or not.
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