Abstract
Background. The dynamics on the remodelation of cortical bone microarchitecture are revealed with increasing accuracy by the use of newly infrared absorption spectra, providing more complex data compared to classical osteodensitometry. The aim of this study was to assess the impact of 2-year biphosphonate treatment on bone loss in a cohort of osteoporotic postmenopausal women with radius fragility fractures. Materials and method. A longitudinal, randomized, 5-year experimental and observational survey was conducted on 156 eligible patients, treated with alendronate, risedronate or zolendronate. Results. Fourier transform infrared spectra from bone biopsy samples revealed compositional information regarding crystalline texture and collagen matrix, allowing a comparative analysis between the initial bone demineralization and the cancellous trabecular bone architecture formed by cortical remodeling exerted by biphosphonates. Conclusions. Monitoring bone remodeling activity is important for guiding biphosphonate therapy.
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