Abstract

Changes in infarct size, platelet aggregation, and plasma 6-k-PGF1 α and thromboxane B2 levels in the coronary sinus and arterial blood were observed in rabbits following acute myocardial infarction with or without trapidil or propranolol treatment. It was found that platelet aggregation, thromboxane B2 and 6-k-PGF1 α were elevated significantly in the control group 6 h after coronary ligation. These changes were inhibited by trapidil as well as propranolol, either of which could limit infarct size remarkably.

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